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KMID : 0358420110540050229
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Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 5 p.229 ~ p.235
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CLINICAL USEFULNESS OF SOLUBLE FMS-LIKE TYROSINE KINASE 1, SOLUBLE ENDOGLIN AND PLACENTAL GROWTH FACTOR IN KOREAN WOMEN WITH PREECLAMPSIA
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Lee Ham-Bak
Kil Ki-Cheol
Nam Sun-Young
Shin Jae-Eun
Cheon Ju-Young
Lee Yong
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Abstract
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Objective To evaluate the clinical signifi cance of soluble fms-like tyrosine kinase1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in preeclampsia.
Methods We conducted a case-control study analyzing serum levels of sFlt-1, sEng and PlGF in women with preeclampsia (n=30) and normal pregnancy (n=30) in the third trimester. We calculated the sensitivity, specifi city, positive, and negative predictive values of each peptide in diagnosing preeclampsia.
Results The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no signifi cant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential signifi cance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specifi city, positive predictive value, negative predictive value was all over 80%. Serum levels of sFlt-1 and sEng were not signifi cantly different between intrauterine growth restriction (IUGR) and non-IUGR group among preeclamptic women.
Conclusion Serum levels of both sFlt-1 and sEng may be useful in diagnosing patients with preeclampsia. The serum levels of these factors may not correlate with poor perinatal outcomes.
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KEYWORD
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Preeclampsia, Soluble fms-like tyrosine kinase 1, Soluble endoglin, Placental growth factor, Intrauterine growth restriction
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